Description
Acid Labile Surfactants (ALS) feature various novel, acid cleavable chemistries that are sample sensitive and fully compatible with mass spectrometry analysis. At neutral pH, Low CMC Acid Labile Surfactant function as gentle, yet powerful chemicals for use in sample preparation, protein solubilization, and cell lysis protocols. After completing experimental work, the solution is adjusted to a pH of 2.5 – 3.0 with trifluoroacetic acid (TFA) and incubated for 10 - 30 minutes to fully cleave the ALS into small organic molecules that do not exhibit surfactant activity or interfere with analysis by mass spectrometry upon removal.
